9 October 2025

Operational approaches and recommendations to interrupt transmission of Mycobacterium leprae

This paper captures the key outcomes of the Global Partnership for Zero Leprosy (GPZL) Zero Transmission Symposium, held from May 23–25 2024 in Bergen, Norway. The symposium brought together global experts to reflect on a decade of progress toward interrupting Mycobacterium leprae transmission and to shape the next phase of operational and research priorities.

The discussions focused on advancing operational approaches for monitoring infection and prevalence, tailoring interventions to local contexts, and scaling programmatic implementation. Key recommendations emerged across six areas—diagnostics, active case detection, post-exposure prophylaxis (PEP) and treatment, antimicrobial resistance surveillance, vaccination, and social determinants of health.

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