SDR-PEP Resources and Tools

Single Dose Rifampicin Post-Exposure Prophylaxis (SDR-PEP) is a preventative treatment for leprosy that can be used to stop the transmission of leprosy to close contacts of leprosy patients. The treatment consists of a single dose of the antibiotic rifampicin (SDR).

This page features resources and tools from GPZL and partners with information for National Leprosy Programme Managers and implementing partners to inform their approach to SDR-PEP.


Leprosy/Hansen disease: Contact tracing and post-exposure prophylaxis

This document provides guidance on how to implement contact screening and chemoprophylaxis with single-dose rifampicin. The contents are logically ordered: counselling and obtaining consent, identification and listing of index case, listing of contacts, tracing of contacts, screening of contacts, administration of prophylactic drugs. Managerial aspects to undertake contact screeninig and chemoprophylaxis are also elaborated, including planning , training , supervision and drug management. Visit site

GPZL Webinars

The Role of Persons Affected in SDR-PEP Implementation

Learn about SDR-PEP, why is it needed, and the role of persons affected by leprosy in successful SDR-PEP implementation. Hear from Alice Cruz, Amar Timalsina, and the WHO Global Leprosy Programme.

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Post Exposure Prophylaxis in Leprosy Programs

Explore the process of starting SDR-PEP with five presentations from leprosy experts and representatives from National Leprosy Programmes that have begun PEP implementation.

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PEP News

Voice of America Logo

GPZL Secretariat Director discusses leprosy prevalence and prevention on Voice of America

2 March, 2021 | Global Partnership for Zero Leprosy

GPZL Secretariat Director, Bill Gallo, sat down with Linord Moudou, host of Voice of America’s Healthy Living series, to discuss leprosy prevalence and the new path toward prevention. The segment, “Fear and Loathing of Leprosy,” opens with perspectives of persons affected … More GPZL Secretariat Director discusses leprosy prevalence and prevention on Voice of America

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Young girl in Nepal receives preventive treatment (SDR-PEP) for leprosy

New NLR study predicts 90% leprosy reduction through preventive treatment of 40 million people in 22 years

2 March, 2021 | NLR International

To interrupt leprosy transmission and reduce annual new cases significantly, contact tracing and preventive treatment needs to be implemented in all leprosy-endemic countries Amsterdam, the Netherlands, March 1, 2021 – New research by NLR, until No Leprosy Remains (NLR) and Erasmus University … More New NLR study predicts 90% leprosy reduction through preventive treatment of 40 million people in 22 years

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International Federation of Anti-Leprosy Associations (ILEP)

Interim advice on the use of rifampicin for post-exposure prophylaxis (PEP)

6 January, 2021 | ILEP Technical Commission

Interim advice on the use of rifampicin for post-exposure prophylaxis (PEP), in light of recent  information on nitrosamine impurities in rifampicin  A number of different problems have affected the supply of rifampicin and MDT to countries this year. The most … More Interim advice on the use of rifampicin for post-exposure prophylaxis (PEP)

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Accelerating Research

A Prioritized Zero Leprosy Research Agenda

4 November, 2020 | Global Partnership for Zero Leprosy

The Global Partnership for Zero Leprosy (GPZL) presented the prioritised Zero Leprosy Research Agenda at the WHO Global Consultation on Global Leprosy Strategy 2021 – 2030 last week. In 2018, the Research Agenda working group’s eight different sub-groups conducted a … More A Prioritized Zero Leprosy Research Agenda

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LPEP Novartis

Contact tracing with prophylactic treatment could near-eliminate leprosy in a single generation, new research suggests

2 November, 2020 | Novartis International AG

Results from the Novartis Foundation-initiated Leprosy Post-Exposure Prophylaxis (LPEP) program covered more than 150,000 people across seven countries Post-exposure prophylaxis with a single dose of the antibiotic rifampicin is safe, can be integrated into different leprosy control programs, and is … More Contact tracing with prophylactic treatment could near-eliminate leprosy in a single generation, new research suggests

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PEP Tools

Risk Maps for Single-Dose Rifampicin Implementation

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Post-Exposure Prophylaxis Package: Start-up

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Post-Exposure Prophylaxis Package: Scale-up

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Post-Exposure Prophylaxis Package: Last Mile

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Integration of Leprosy, Disability and WASH Programs

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Household Contact Examinations before Post-Exposure Prophylaxis

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Screening Index Cases for Post-Exposure Prophylaxis

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Health Care Staff Involvement in Post-Exposure Prophylaxis

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Counseling of Index Cases by Health Care Staff

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PEP Country Work

Examples of PEP Packages

Start-up: Nigeria Scale-Up: Nepal Last-Mile: Morocco

Presentations: Countries’ Experiences with SDR-PEP

Morocco Indonesia Brazil